In fact, the main regulation hormone, called Thyroid Stimulating Hormone (TSH), is made up partly of glucose molecules (2).
In addition to these important roles, carb intake appears to influence the amount of T3 that gets converted from T4 thyroid hormone. This is important for hypothyroidism as T3 is the active thyroid hormone that you need to increase.
It appears that when carb intake is drastically reduced, conversion of T3 from T4 declines (3).
Summary: Glucose and thyroid hormones rely on each other synergistically. The amount of carbs eaten can affect amount of T3 converted from T4.
Will Cutting Carbs Inhibit Hormone Production?
It’s known that a state of prolonged calorie restriction or fasting reduces T3 hormone production.
This occurs to slow down metabolism, increasing chances of survival when our ancestors were in times of food shortage (6).
Of course, lower T3 (and therefore a slower metabolism) is typically undesirable when food is abundant… especially for those with an underactive thyroid.
A ketogenic diet mimics starvation or fasting, at least from a metabolic point of view (7).
This means it may limit T3 production and potentially influence metabolism.
In one of the studies, researchers evaluated the effects of restricting carbs at various levels (85, 44 and 2% of total energy intake) on thyroid hormones in 6 healthy male participants.
Results found that the high carbohydrate diet had no impact, whereas the very low carbohydrate diet did. It caused decreased T3 levels, increased rT3 and free T4 levels (8).
Average T3 plasma concentrations after 11 days of high carbohydrate diet (white), control diet (grey) and low carbohydrate diet (black) in 6 healthy males. The * indicates a significantly lower T3 level for the low carbohydrate diet, which is not desirable in hypothyroidism.
These results are similar to those of another study where participants received an 800 calorie diet comprising of either 0%, 25% or 100% carbohydrate, for a period of 2 weeks.
The results showed T3 levels were reduced from both fasting and the 0% carbohydrate diet, but not from the 100% carbohydrate diet (11).
What About Lower Carb, Not Ketogenic?
Simply reducing carb intake lower than normal – without ketosis – is unlikely to influence thyroid hormone levels (5).
A study of 17 obese patients on a 440 kcal diet for 3 weeks found those on the 1% carb diet had greater decreases in T3 levels compared to the 55% carb group (12).
So perhaps the further carbs are restricted, the more T3 hormone is reduced.
However, we must acknowledge the limitations of all these clinical trials I’ve mentioned:
- Tiny sample sizes
- Relatively short duration
- Tend to use obese individuals, and may not be applicable to non-obese individuals
- Studies were also not specific to individuals with existing hypothyroidism.
How directly we can apply the findings to a middle-aged man or woman with hypothyroidism is difficult to say.
But considering a long-term ketogenic diet can cause other hormonal imbalances (particularly in women) it seems unnecessarily risky in these circumstances.
Summary: Severe calorie restriction appears to limit the conversion of T3 from T4, which is undesirable for hypothyroidism. Studies suggest a very low carb ketogenic diet may have a similar effect because of the way it mimics starvation or fasting (metabolically). However, moderate low carb diets are likely safe.
If you exercise frequently for prolonged periods, your carbohydrate and calorie requirements will be greater than average.
It’s important to consider this if planning to reduce carb intake.
Additionally, low carb diets have been known to increase the “bad” LDL cholesterol in select individuals, likely due to an increased saturated fat intake.
Consider this if you are at risk for heart disease, and be sure to have routine blood tests.
As always, it’s recommended you speak with your doctor or dietitian before making any major diet changes.
A low carb diet can help with weight loss and maintenance, particularly for those with an underactive thyroid.
Current research on the topic is limited, but it seems safe.
However, a very low carb or ketogenic diet is not recommended.
Studies suggest it inhibits the conversion of T4 into T3 (active thyroid hormone), which is undesirable for those with hypothyroidism.
If you are thinking of following a low carb diet, this is a great starting point.
This article was originally published on Diet vs Disease.